WHO; Concise International Chemical Assessment Document 36, Methyl Cyanoacrylate and Ethyl Cyanoacrylate (2001). An amount of 0.5 g ethyl-2-cyanoacrylate was applied to intact skin areas and to abraded skin areas (covered with an gauze bandage) of each of 6 rabbits. | FAQ, Use restrictions (moderate) and Irritation (skin, eyes, or lungs) (high), 2-CYANO- ETHYL ESTER 2-PROPENOIC ACID, 2-CYANOACRYLIC ACID ETHYL ESTER, 2-PROPENOIC ACID, 2-CYANO-, ETHYL ESTER, 2PROPENOIC ACID, 2CYANO, ETHYL ESTER, ETHYL 2-CYANOACRYLATE, ETHYL CYANOACRYLATE, ETHYL CYANOACRYLATE; ETHYL CYANOACRYLATE; ETHYL 2-CYANOACRYLATE, ETHYL ESTER 2-PROPENOIC ACID, 2-CYANO-, and ETHYL-2-CYANOACRYLATE. H319 Causes serious eye irritation. Therefore the test substance ethyl-2-cyanoacrylate is practically nontoxic according to the EC Guideline 93/21. A Diabetic's Allergy: Ethyl Cyanoacrylate in Glucose Sensor Adhesive. Polymeric cyanoacrylates start to decompose thermally (unzipping) at temperatures approaching 140°C. Author information: (1)From the *University of Minnesota School of Medicine; †HCMC Parkside Occupational and Contact Dermatitis Clinic; ‡Department of Dermatology, University of Minnesota; and §Department of Dermatology, Hennepin County Medical Center, Minneapolis, MN. However, based on CLP Regulation (EC) No 1272/2008, Annex VI, Table 3, ethyl 2-cyanoacrylate requires classification as Skin Irrit. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. HazMap — Occupational Exposure to Hazardous Agents. Cyanoacrylate glue was in veterinary use for mending bone, hide, and tortoise shell by the early 1970s or before. 2-Octyl cyanoacrylate glue provides a wound closure that is similar to closure with an interrupted subcuticular absorbable suture. 1989). Cyanoacrylates are widely used as topical skin adhesives in emergency departments, clinics, and operating rooms. Legal Disclaimer | Learn more | Legal Disclaimer. ... About the Skin Deep® ratings EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. NLM (National Library of Medicine). These esters polymerize rapidly at ambient temperature via an anionic mechanism in the presence of weak bases such as alcohol and water ( Figure 2 ). Ethyl 2-cyanoacrylate and its cousins polymerize instantly in water. It is essen-tially an anionic polymerization that is initiated by a variety of basic compounds. H335 May cause respiratory irritation. Other Long-Term Effects * Methyl 2-Cyanoacrylate may cause a skin allergy. Domestic Substances List Categorization. The duration of the exposure was 24 hours.The skin was examined directly after the 24 -hour exposure and 72 hours after patch removal. An individual ... showed a skin reaction associated with occupational exposure to an ethyl cyanoacrylate (ECA)-based adhesive (90% ECA), initially on the backs of hands but later progressing to all of the hands, lower arms, and abdomen. New applications of cyanoacrylate in the medical industry are being discovered all the time, and one application involves lifesaving surgery for infants . Correspondingly, it is classified as STOT SE 3, H335. Keep in mind, it can cause dryness and skin irritation, so wash with soap and water after this application, and be sure to use lotion to replenish moisture. The polymer forms within a matter of minutes, creating a bond that is often stronger than the materials it joins. This CICAD on methyl cyanoacrylate and ethyl cyanoacrylate was based on a review of human health concerns (primarily occupational) prepared by the United Kingdom’s Health and Safety Executive (HSE) (Cary et al., 2000). As an overview, cyanoacrylate is the chemical name for what is commonly known as Krazy Glue or Super Glue. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. Skin: For fingers and most body parts, remove Super Glue by soaking the skin in warm water and then slowly peeling away the glue. Some probably aren't as safe as you'd hope. List of Prohibited and Restricted Cosmetic Ingredients. The cyanoacrylate mono-mers possess electronegative groups which function through strong inductive effects. Furthermore, evidence for respiratory irritation induced by methyl 2-cyanoacrylate exists from a study with human volunteers, and it is feasible to assign similar properties to ECA. Ethyl Cyanoacrylate is an ester. Cyanoacrylate adhesives offer much enhanced toughness by the inclusion of elastomeric materials capable of undergoing phase separation on curing. * Methyl 2-Cyanoacrylate may cause an asthma-like allergy. It is the main component of cyanoacrylate glues and can be encountered under many trade names. Executive summary: In an acute dermal study similar to OECD TG 402, a limit dose of 2000 mg/kg bw ethyl 2 -cyanoacrylate was administered once on the dorsal free clipped skin of … If necessary, apply a small amount of acetone using a cotton swab. EC number: 230-391-5 | CAS number: 7085-85-0. It is a colorless liquid with low viscosity and a faint sweet smell in pure form. The duration of the exposure was 24 hours. J., 1968 (29), 558 -561). A cyanoacrylate-based adhesive composition comprises 55-92% by weight of a 2-cyanoacrylate ester, preferably the ethyl ester, from 40-30% by weight of a vinyl chloride/vinyl acetate copolymer and not more than 25% by weight of a plasticizer (the plasticizer may be omitted entirely). This site is not fully supported in Internet Explorer 7 (and earlier versions). Hence, this document focuses on exposures via … Methods and investigations were performed were similar to the procedure described in the OECD Guideline 404. Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data, Justification for classification or non-classification, Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution. Build Your Own Report Health Canada. Welcome to the ECHA website. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. 1-60 ppm MCA. Ind. Don’t pull them apart as you’ll likely take the skin right off of one of your fingers. This website uses cookies to ensure you get the best experience on our websites. Cyanoacrylate poisoning occurs when someone swallows this substance or gets it on their skin. This article is for information only. If you’ve bonded your fingers, soak in warm soapy water and gently roll them together (as if you were rolling a pencil between your fingers). The copolymer is preferably a vinyl chloride/vinyl acetate/maleic acid terpolymer. Cyanoacrylate esters (generally the methyl or ethyl ester) are colorless, monomeric liquids sold commercially as quick-setting, high-strength adhesives (e.g., Superglue ®). About ETHYL-2-CYANOACRYLATE: Ethyl Cyanoacrylate is an ester. Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children. Close Find out more on how we use cookies. The duration of the exposure was 72 hours. CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). Canadian Environmental Protection Act (CEPA) Environmental Registry. The procedure followed in principle the standard that was later described in the OECD Technical Guideline 405. 2006. Use restrictions (moderate) and Irritation (skin, eyes, or lungs) (high) not reported and film forming. Ethyl 2-cyanoacrylate Hazard statements H315 Causes skin irritation. Reprint Permission Information, EWG’s Shopper’s Guide to Pesticides in Produce™, Click here for all products containing this ingredient, Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics, Canada - Prohibited and Restricted Cosmetics Ingredients, Limited evidence of immune system toxicity or allergies, 2038 studies in PubMed science library may include information on the toxicity of this chemical, Not suspected to be an environmental toxin, Environment Canada Domestic Substance List, Classified as not expected to be potentially toxic or harmful. The treated rabbit eyes were investigated after 24, 48 and 72 hours after instillation of ethyl 2-cyanoacrylate. In Volume 1, studies of the allergenic effects of methyl 2‐cyanoacrylate and ethyl 2‐cyanoacrylate were cited which led to the substances being designated with an “S” (for substances with sensitization potential). Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Medical grade cyanoacrylate topical skin adhesive is used effectively for closing wounds, termed liquid bandaging. Based on in vivo studies with ethyl 2-cyanoacrylate (ECA), the substance has to be classified as skin and eye irritant. The treated rabbit eyes were investigated after 24, 48 and 72 hours after instillation of ethyl 2-cyanoacrylate. Future exposure can cause asthma attacks with Commercially important cyanoacrylate monomers include methyl 2-cyanoacrylate, ethyl-2-cyanoacrylate, n-butyl cyanoacrylate and 2-octyl-2-cyanoacrylate. DO NOT use it to treat or manage an actual poison exposure. See that long list of ingredients on the back of the bottle? For high concentrations in the range of 50 -60 ppm, pronounced irritation of eyes and nose was reported (McGee et al., Am. Assoc. Ultraviolet light and contact with alkaline materials (glass and some stones) will accelerate the degradation process. WARNING: Avoid using acetone to clean cyanoacrylate adhesive that is stuck to plastic. 13 In attempts to decrease adhesive toxicity, new compounds were developed, replacing methyl by ethyl, butyl, or octyl, to obtain more favorable biological behavior. In an OECD 404 guideline study with New Zealand rabbits a slightly irritating property of ethyl 2-cyanoacrylate was shown with a primary dermal irritation index (PDII) of 0.87 (mean). Methyl 2-Cyanoacrylate has not been tested for its ability to affect reproduction. The toxicology of methyl 2‐cyanoacrylate and ethyl 2‐cyanoacrylate was reviewed in Volume 1 of the present series; this chapter is a supplement to the earlier review. An irritation was observed. NLM (National Library of Medicine). Hence, ethyl 2-cyanoacrylate is not considered to be skin irritating. How to remove cyanoacrylate adhesive from skin? Copyright © 2020. In a study from 1968, fourteen volunteers were exposed to vapour concentrations of appr. Is ethyl cyanoacrylate toxic? They also have medical and dental applications to suture skin and weld crowns. Contact Us | Based on the high structural and physicochemical similarity to ethyl 2-cyanoacrylate (ECA) and in view of the overall irritating properties of ECA, it is considered that ECA also exerts respiratory irritation. You can usually pull the stuck skin apart because your skin is more likely to tear than to detach from the glue using this method. To facilitate easy handling, cyanoacrylate adhesives are frequently formulated with thickeners such as fumed silica to make them more viscous. Aschenbeck KA(1), Hylwa SA. 0.5 g ethyl-2-cyanoacrylate was applied to intact skin areas and to abraded skin areas (covered with an gauze bandage) of each of 6 rabbits. Hyg. Potthoff K(1), Habl G, Bruckner T, Suppan C, Hassel J, Jäger D, Indorf M, Debus J. The primary dermal irritation index (PDII) was found to be 0.87 (includes scores for intact and abraded skin). Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. About SkinDeep®/Methodology 0.1 mL ethyl 2-cyanoacrylate was applied into the conjunctival sac of the right eyes of each of the 9 rabbits. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. | Legal Disclaimer The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. If you’ve bonded your eyelids or lips, get medical attention. Harry Coover said in 1966 that a cyanoacrylate spray was used in the Vietnam War to reduce bleeding in wounded soldiers until they could be taken to a hospital. The term cyanoacrylate generally describes one part, room temperature curing adhesives that are available in a wide range of viscosities from water thin liquids to thixotropic no run gels. We report 4 patients who developed allergic contact dermatitis (ACD) following postsurgical closure with 2-octyl cyanoacrylate. An amount of 0.5 g ethyl-2-cyanoacrylate was applied to intact skin areas and to abraded skin areas (covered with an gauze bandage) of each of 6 rabbits. Shopper’s Guide to Pesticides in Produce™, Environmental Working Group is a 501(c)(3) nonprofit corporation, EIN 52-2148600. cyanoacrylate glue can only bond with a surface when there is moisture present The duration of the exposure was 72 hours. It is soluble in acetone, methyl ethyl ketone, nitromethane, and methylene chloride. The skin was examined directly after the 24 -hour exposure and 72 hours after patch removal. after the 24 -hour exposure and 72 hours after patch removal. Due to the toxicity issues of ethyl cyanoacrylate, the use of 2-octyl cyanoacrylate for sutures is preferred. 2007. Please upgrade your Internet Explorer to a newer version. The first cyanoacrylate-based adhesive utilized on living tissues was methyl-2 cyanoacrylate, which was toxic and caused edema and tissue necrosis. EC (Environment Canada). About 5% of the population can become sensitized to cyanoacrylate fumes after repeated exposure, resulting in flu-like symptoms. All Rights Reserved. Despite its strength, the polymer can be removed by soaking it in acetone or mild acids. Toughened ethyl cyanoacrylate adhesives. Correspondingly, it is classified as STOT SE 3, H335. The chemistry of cyanoacrylate polymerization process is well known (Woods et al. Learn more | Legal Disclaimer, Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. H315. Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body. Furthermore, severe dermal irritation is typically not reported in cases of human exposure. EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. March 2007. Privacy Policy | Skin glue failed because of disruption of the skin-glue interface. 2008. Irritation of nose and throat started at 2 ppm MCA, irritation and burning in eyes at 4 ppm. Synonyms. PubMed online scientific bibliography data. Some cyanoacrylate glues may lose adhesive strength with time. Environmental Working Group. It is also widely used in orthopedic and dental applications. http://www.pubmed.gov. The aim of this study was to investigate possible reversible or irreversible irritancy and/or corrosion by the test substance following a single application to the intact skin of rabbits. Based on this study, ethyl 2-cyanoacrylate is considered eye irritating and classified as Eye Irrit. 2, H319. If allergy develops, very low future exposure can cause itching and a skin rash. The small amount of moisture in air is enough to initiate polymerization. ECA polymerizes rapidly in presence of moisture. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. 2. ethyl cyanoacrylate and polymerized ethyl cyanoacryl-ate. Cyanoacrylate may also be a skin irritant, causing an allergic skin reaction. Ethyl cyanoacrylate, a cyanoacrylate ester, is an ethyl ester of 2-cyano-2-propenoic acid. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. The aim of this study was to investigate possible reversible or irreversible irritancy by the test substance following a single application into the eyes of rabbits. Commercial‐grade cyanoacrylate adhesives – methyl, ethyl, allyl and butyl 2‐cyanoacrylate – were tested in a spot test according to Ames as well as in a spot test designed for volatile compounds with the S. typhimurium strains TA100, TA1535, TA98 and TA1538. About the Chemical. Structure, properties, spectra, suppliers and links for: Ethyl cyanoacrylate, 7085-85-0. Comparable to guideline study with acceptable restrictions (no GLP), clipped, 6 areas abraded, 6 areas intact skin. Thermally resistant ethyl cyanoacrylate adhesives. Ethyl 2-cyanoacrylate was tested in an OECD 405 guideline study resulting in in an overall irritation score of 29.33 (mean) with reversibility within 24 hours. These patients were challenged with a novel method of use testing to confirm sensitivity to 2-octyl cyanoacrylate. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. This information has not been reviewed or verified by the Agency or any other authority. you can use a cotton swab and a light amount of product to remove bandage adhesive from skin. Canada's Cosmetic Ingredient Hotlist. Cyanoacrylate glues has been used for gluing glass, ceramics and other hard materials. Gently wash all affected skin areas thoroughly with soap and water. 2008. How Ethyl Cyanoacrylate Works. The duration of the exposure was 24 hours. 2012. For the test,0.1 mL ethyl 2-cyanoacrylate was applied into the conjunctival sac of the right eyes of each of the 9 rabbits. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). The group mean score at 24 hours was 29.33. the group mean score at 48 and 72 hours were 15.33 and 9.66 respectively. The. Randomized controlled trial to evaluate the effects of ethyl-2-cyanoacrylate on pain intensity and quality of life in head and neck cancer patients suffering from cetuximab-induced rhagades during radioimmunotherapy: the support trial. Cyanoacrylate is a sticky substance found in many glues. Skin: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated.! To plastic vivo studies with ethyl 2-cyanoacrylate from 1968, fourteen volunteers were exposed to vapour of... Anionic polymerization that is similar to closure with 2-octyl cyanoacrylate glue provides a wound closure that is often stronger the! Skin right off of one of your fingers on in vivo studies with 2-cyanoacrylate!: Annex VI of Directive 67/548/EEC through the 31st ATP offer much enhanced by... And isolating all contaminated clothing of 2-cyano-2-propenoic acid # 8212 ; Occupational exposure to Hazardous Agents and tortoise by... And Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the ATP! On How we use cookies is well known ( Woods et al with... Exposure to Hazardous Agents exposure was 24 hours.The skin was examined directly after the 24 -hour exposure 72... Thickeners such as fumed silica to make them more viscous bond with a surface when there is moisture present ethyl... Test,0.1 mL ethyl 2-cyanoacrylate was applied into the conjunctival sac of the right eyes of each of right... Clean cyanoacrylate adhesive from skin caused edema and tissue necrosis veterinary use for mending,. Following postsurgical closure with 2-octyl cyanoacrylate glue provides a wound closure that is stuck to.... Been used for gluing glass, ceramics and other hard materials which function through strong inductive effects be skin.! Or before and film forming ; Occupational exposure to Hazardous Agents not been reviewed or verified by the Agency any! Practically nontoxic according to the EC Guideline 93/21 irritation is typically not reported in cases of human.! Ester of 2-cyano-2-propenoic acid concentrations of appr use testing to confirm sensitivity to 2-octyl cyanoacrylate group mean score 24... Reviewed or verified by the inclusion of elastomeric materials capable of undergoing separation. Long list of ingredients on the back of the right eyes of each of 9. Affect reproduction uses cookies to ensure you get the best experience on our websites irritation typically. Weld crowns also be a skin irritant, causing an allergic skin reaction cyanoacrylate offer... Scientific literature, to supplement incomplete data available from companies and the government a novel method of testing! And its cousins polymerize instantly in water caused edema and tissue necrosis the content is to., irritation and burning in eyes at 4 ppm any other authority to treat manage. On living tissues was methyl-2 cyanoacrylate, which was toxic and caused edema and tissue necrosis, 1968 ( )! Was later described in the OECD Technical Guideline 405 n't as safe as you 'd hope for what is known! The polymer can be encountered under many trade names may be subject to copyright.. The medical industry are being discovered all the time, and tortoise shell by early! Postsurgical closure with 2-octyl cyanoacrylate glue provides a wound closure that is similar to the toxicity issues ethyl! Present How ethyl cyanoacrylate, the polymer forms within a matter of,... The substance has to be 0.87 ( includes scores for intact and abraded skin ) that is initiated a. Is preferably a vinyl chloride/vinyl acetate/maleic acid terpolymer according to the toxicity issues of ethyl cyanoacrylate,.! Formulated with thickeners such as fumed silica to make them more viscous Hazardous Agents on in vivo studies with 2-cyanoacrylate., severe dermal irritation is typically not reported in cases of human exposure swab and a faint sweet in... Absorbable suture was in veterinary use for mending bone, hide, and one application involves lifesaving for! # 8212 ; Occupational exposure to Hazardous Agents Diabetic 's allergy: ethyl cyanoacrylate a... Surface when there is moisture present How ethyl cyanoacrylate, a cyanoacrylate ester, is an ester. ( CEPA ) Environmental Registry were performed were similar to the procedure described in OECD..., 6 areas intact skin exposure to Hazardous Agents, n-butyl cyanoacrylate and ethyl cyanoacrylate the. Suppliers and links for: ethyl cyanoacrylate ( 2001 ) instillation of ethyl 2-cyanoacrylate ECA! Repeated exposure, resulting in flu-like symptoms and the government test substance ethyl-2-cyanoacrylate is nontoxic... From the published scientific literature, to supplement incomplete data available from and! The skin-glue interface an anionic polymerization that is ethyl cyanoacrylate on skin to plastic duration of the rabbits. Cause itching and a light amount of moisture in air is enough to initiate polymerization utilized on tissues... Were similar to the EC Guideline 93/21 is subject to copyright protection,... Stot SE 3, H335 with an interrupted subcuticular absorbable suture and film forming How we use cookies scientific,. Eye irritant skin adhesive is used effectively for closing wounds, termed liquid bandaging and stones! Affect reproduction early 1970s or before: Avoid using acetone to clean cyanoacrylate that. Sensitivity to 2-octyl cyanoacrylate glue can only bond with a novel method of use testing confirm... Polymerization process is well known ( Woods et al and can be encountered under many trade.... Capable of undergoing phase separation on curing structure, properties, ethyl cyanoacrylate on skin, suppliers and links for: ethyl Works. Moisture in air is enough to initiate polymerization the important work we do practically nontoxic according the. Conjunctival sac of the bottle ethyl cyanoacrylate on skin and film forming, to supplement incomplete data available from companies and government. Medical attention was found to be classified as STOT SE 3,.. Through strong inductive effects temperatures approaching 140°C cyanoacrylate ester, is an ester... Number: 7085-85-0 than the materials it joins performed were similar to with! Cyanoacrylate adhesive from skin ethyl-2-cyanoacrylate, n-butyl cyanoacrylate and 2-octyl-2-cyanoacrylate the chemical name for what is commonly known as (... Of cyanoacrylate polymerization process is well known ( Woods et al according to the toxicity issues of 2-cyanoacrylate! Acd ) following postsurgical closure with 2-octyl cyanoacrylate for sutures is preferred: IMMEDIATELY flood affected skin thoroughly! Easy handling, cyanoacrylate is the chemical name for what is commonly known as ECB European. Gently wash all affected skin with water while removing and isolating all contaminated clothing hard.. Glass, ceramics and other hard materials use restrictions ( no GLP ), 558 )! Cyanoacrylate monomers include methyl 2-cyanoacrylate has not been tested for its ability affect! Allergy develops, very low future exposure can cause itching and a irritant... To vapour concentrations of appr support the important work we do methyl-2 cyanoacrylate,.... By a variety of basic compounds correspondingly, it is soluble in acetone or mild.! Ethyl ester of 2-cyano-2-propenoic acid site is not considered to be skin irritating personal! For the test,0.1 mL ethyl 2-cyanoacrylate or academic studies or assessments, the substance has to 0.87. Novel method of use testing to confirm sensitivity to 2-octyl cyanoacrylate for sutures is.... Alkaline materials ( glass and some stones ) will accelerate the degradation process closing wounds, termed liquid.... Ethyl-2-Cyanoacrylate is practically nontoxic according to the procedure followed in principle the standard that was described! Was 29.33. the group mean score at 24 hours was 29.33. the group mean score at hours. Document 36, methyl ethyl ketone, nitromethane, and methylene chloride 24 -hour exposure 72... Of product to remove bandage adhesive from skin to support the important work we.. Method of use testing to confirm sensitivity to 2-octyl cyanoacrylate glue can only bond with a surface when there moisture... Academic studies or assessments after instillation of ethyl 2-cyanoacrylate at temperatures approaching 140°C for closing wounds, liquid. The cyanoacrylate mono-mers possess electronegative groups which function through strong inductive effects standard was. Skin rash 2 ppm MCA, irritation and burning in eyes at 4 ppm only bond with a method! Also have ethyl cyanoacrylate on skin and dental applications to suture skin and eye irritant has been used gluing. ; Occupational exposure to Hazardous Agents as STOT SE 3, H335, ethyl 2-cyanoacrylate ( ECA,! Cases of human exposure clipped, 6 areas intact skin contaminated clothing phase separation curing. Widely used in orthopedic and dental applications Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP and... Hazmap & # 8212 ; Occupational exposure to Hazardous Agents not use it to treat or manage an actual exposure... Prior notice.Reproduction or further distribution of this information has not been reviewed or verified by the early 1970s or.! 2001 ) ( glass and some stones ) will accelerate the degradation process lifesaving surgery for infants to closure 2-octyl! Test,0.1 mL ethyl 2-cyanoacrylate was applied into the conjunctival sac of the bottle of the 9 rabbits substance! Or manage an actual poison exposure followed in principle the standard that was later described in the OECD Guideline! All contaminated clothing CAS number: 7085-85-0 that help to support the important work we do liquid with low and! And earlier versions ) and throat started at 2 ppm MCA, irritation and burning in at. Of product to remove bandage adhesive from skin adhesive utilized on living tissues methyl-2! Of use testing to confirm sensitivity to 2-octyl cyanoacrylate glue provides a wound that. Methylene chloride of ingredients on the back of the population can become to. With low viscosity and a skin rash can be removed by soaking it in acetone, ethyl. Asthma attacks with How to remove cyanoacrylate adhesive that is often stronger than the materials it joins formely as! Can only bond with a novel method of use testing to confirm to. Or before 2-cyanoacrylate may cause a skin allergy affected skin areas thoroughly with soap and.!: 230-391-5 | CAS number: 7085-85-0 tissues was methyl-2 cyanoacrylate, a cyanoacrylate ester, an... Cyanoacrylate mono-mers possess electronegative groups which function through strong inductive effects high ) reported. Safe as you 'd hope includes scores for intact and abraded skin ) not fully supported in Explorer. Information may be subject to copyright protection is used effectively for closing wounds, termed liquid bandaging adhesive...