Bloomberg the Company & Its Products The Company & its Products Bloomberg Terminal Demo Request Bloomberg Anywhere Remote Login Bloomberg Anywhere Login Bloomberg Customer Support Customer Support The science of Tumor Treating Fields extends beyond glioblastoma. The science of Tumor Treating Fields extends beyond glioblastoma. Patients may have had a maximum of two prior lines of systemic therapy following diagnosis of platinum-resistance. In 2019, Novocure collaborated with Zai Lab to begin a phase 2 pilot trial of Tumor Treating Fields in gastric cancer in Greater China. This website intends to use cookies to improve the site and your experience. “We are excited about the potential of TTFields for the treatment of advanced NSCLC, and we are pleased to start this pivotal trial.”. Novocure has enrolled the first patient in Phase 3 TRIDENT trial, evaluating Optune, a non-invasive, antimitotic cancer treatment, used concurrent with radiation therapy in newly diagnosed glioblastoma (GBM). The primary endpoint is superior overall survival of patients treated with TTFields plus immune checkpoint inhibitors or docetaxel versus immune checkpoint inhibitors or docetaxel alone. Forward-looking statements provide Novocure’s current expectations or forecasts of future events. In 31 evaluable patients, the INNOVATE trial suggested a more than doubling of progression free survival and an improvement in overall survival among patients who received Optune with paclitaxel compared to paclitaxel alone. acordova@novocure.com Novocure has ongoing or completed phase 2 pilot trials investigating TTFields in non-small cell lung cancer, pancreatic cancer, ovarian cancer and mesothelioma. An oral presentation will focus on how compliance and treatment duration may predict survival in newly diagnosed glioblastoma patients treated with Optune® together with... | January 23, 2021 The LUNAR trial design was based on preclinical findings that suggest TTFields may act synergistically with certain taxanes and enhance the efficacy of immune checkpoint inhibitors. Novocure Initiates Phase 3 Pivotal Trial in Recurrent Ovarian Cancer INNOVATE-3 will test the efficacy of Tumor Treating Fields combined with … The EF-15 study showed that TTFields are safe and tolerable in patients with advanced NSCLC. Ovarian cancer is one of the most … Based on these results, Novocure plans to start a phase 3 trial in recurrent ovarian cancer in 2018. View source version on businesswire.com: https://www.businesswire.com/news/home/20190322005019/en/, Media and Investor Contact: Ovarian cancer has been an important area of focus for our research because of the great unmet need faced by these patients. For additional information about the company, please visit www.novocure.com or follow us at www.twitter.com/novocure. In the United States, ovarian cancer ranks fifth in cancer deaths among women, accounting for more deaths than any other cancer of the female reproductive system. In addition to historical facts or statements of current condition, this press release may contain forward-looking statements. This was driven by an increase in expenses for Novocure's phase 3 pivotal and post-marketing trials, as well as expenses to support product development programs, and investments in … For additional information about the company, please visit www.novocure.com or follow us at www.twitter.com/novocure. The international trial is planned to include 512 patients with stage IIIB and IV NSCLC of all histologies after failing platinum-based therapy. Tumor Treating Fields (TTFields) therapy is not approved for the treatment of NSCLC by the U.S. Food and Drug Administration. Novocure is a commercial-stage oncology company developing a proprietary therapy called Tumor Treating Fields, or TTFields, for the treatment of solid tumor cancers. Novocure announced today that the first patient has been enrolled in LUNAR, its phase 3 pivotal trial of Tumor Treating Fields at 150 kHz as a treatment for advanced non-small cell lung cancer. Novocure has ongoing or completed clinical trials investigating Tumor Treating Fields in mesothelioma, brain metastases, non-small cell lung cancer, pancreatic cancer, ovarian cancer and liver cancer. Novocure has ongoing or completed phase 2 pilot trials investigating TTFields in non-small cell lung cancer, pancreatic cancer, ovarian cancer and mesothelioma. Novocure has ongoing phase 3 pivotal trials in brain metastases from NSCLC and in advanced NSCLC after failing platinum-based therapy. Additionally, the company has offices in Germany, Switzerland, Japan and Israel. Any forward-looking statements herein speak only as of the date hereof. METIS is Novocure’s first phase 3 pivotal trial outside of glioblastoma. Meet our leaders, who have extensive experience across oncology, biotechnology and medical device industries. Headquartered in Jersey, Novocure has U.S. operations in Portsmouth, New Hampshire, Malvern, Pennsylvania, and New York City. Novocure developed the trial design for INNOVATE-3 after learning the results of its phase 2 pilot trial of Tumor Treating Fields in combination with weekly paclitaxel, the INNOVATE trial. “At Novocure, we strive to extend survival in some of the most aggressive forms of cancer. Ovarian cancer incidence increases with age, and the median age at time of diagnosis is 63 years old. The Private Securities Litigation Reform Act of 1995 permits this discussion. “Ovarian cancer is one of the most aggressive forms of cancer,” said Professor Ignace Vergote, Chairman of the Department of Obstetrics and Gynaecology and Gynaecologic Oncology at the Catholic University of Leuven, European Union. By continuing to browse the site you are agreeing to accept our use of cookies. Professor Vergote said he plans to participate. Stupp R, Taillibert S, Kanner A, et al. Novocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer by developing and commercializing its innovative therapy, Tumor Treating Fields. “We designed this trial to test TTFields with two of the currently available standard of care treatments for advanced NSCLC following failure of platinum-based therapy, opening the trial to more patients with this disease,” said Dr. Eilon Kirson, Novocure’s Chief Science Officer and Head of Research and Development. JAMA. Therefore, you should not rely on any such factors or forward-looking statements. ST. HELIER, N.J., Oct. 12, 2016 (GLOBE NEWSWIRE) — Novocure (NASDAQ:NVCR) announced today that the first patient has been enrolled in the METIS trial, a phase 3 pivotal trial studying radiosurgery plus Tumor Treating Fields (TTFields) compared to radiosurgery alone for the treatment of brain metastases from non-small cell lung cancer (NSCLC).). The safety and effectiveness of Tumor Treating Fields for ovarian cancer has not been established. We pioneer a profoundly different approach to treating cancer called Tumor Treating Fields. Patient images reflect the health status of the patients at the time each photo or video was taken. If you require further information and/or do not wish to have cookies placed when using the site, review the Cookies section of our Website Privacy Policy or visit www.allaboutcookies.org. “I’ve always been very interested in innovation and trying to find new treatment modalities to help our patients,” he said. On this site, videos and images identified as Optune users, caregivers or healthcare professionals depict actual patients, caregivers and healthcare professionals. In addition to historical facts or statements of current condition, this press release may contain forward-looking statements. Novocure (NASDAQ: NVCR) announced today that it has initiated INNOVATE-3, a phase 3 pivotal trial testing the efficacy of Tumor Treating Fields combined with paclitaxel in patients with recurrent, platinum-resistant ovarian cancer. The PANOVA-3 trial (also known as the “EF-27 trial”) is a pivotal (analogous to a drug Phase III), randomized controlled trial, designed to test the efficacy and safety of Tumor Treating Fields (TTFields), generated by a medical device, the NovoTTF-100L(P) System [About TTFields] in combination with gemcitabine and nab-paclitaxel as front-line treatment for patients with … INNOVATE-3, a phase 3 pivotal trial testing the efficacy of Tumor Treating Fields combined with paclitaxel in patients with recurrent, platinum-resistant ovarian cancer. We have revised our Privacy Policy that is in effect as of May 25, 2018. Novocure (NASDAQ: NVCR) announced today that it has initiated INNOVATE-3, a phase 3 pivotal trial testing the efficacy of Tumor Treating Fields combined with paclitaxel in patients with recurrent, platinum-resistant ovarian cancer.INNOVATE-3 is Novocure’s fourth phase 3 pivotal trial initiated to study solid tumors beyond glioblastoma. INNOVATE-3, a prospective, open-label study, will include 540 patients with recurrent, platinum-resistant ovarian cancer. Therefore, you should not rely on any such factors or forward-looking statements. The Private Securities Litigation Reform Act of 1995 permits this discussion. Please click here to access it. Novocure announces the EF-14 phase 3 pivotal clinical trial stopped for early success at interim analysis. Novocure has ongoing or completed clinical trials investigating Tumor Treating Fields in mesothelioma, brain metastases, non-small cell lung cancer, pancreatic cancer, ovarian cancer and liver cancer. Novocure’s performance and financial results could differ materially from those reflected in these forward-looking statements due to general financial, economic, regulatory and political conditions as well as more specific risks and uncertainties facing Novocure such as those set forth in its Annual Report on Form 10-K filed on March 1, 2016, with the U.S. Securities and Exchange Commission. Any forward-looking statements herein speak only as of the date hereof. Tumor Treating Fields is a cancer therapy that uses electric fields tuned to specific frequencies to disrupt solid tumor cancer cell division. Please click here to access it. “Most ovarian cancer patients are diagnosed at an advanced stage, which makes the disease difficult to treat. We are now working closely with trial sites and institutional review boards to open sites and enroll patients as quickly as possible.”. Novocure has ongoing or completed clinical trials investigating Tumor Treating Fields in mesothelioma, brain metastases, non-small cell lung cancer, pancreatic cancer, ovarian cancer and liver cancer. Novocure has grown significantly in the past several years. Novocure has ongoing phase 3 pivotal trials in brain metastases from NSCLC and in advanced NSCLC after failing platinum-based therapy. Bloomberg the Company & Its Products The Company & its Products Bloomberg Terminal Demo Request Bloomberg Anywhere Remote Login Bloomberg Anywhere Login Bloomberg Customer Support Customer Support “We have a clear, unmet need for an effective treatment for brain metastasis, a … “Ovarian cancer is one of the most aggressive forms of cancer,” said Professor Ignace Vergote, Chairman of the Department of Obstetrics and Gynaecology and Gynaecologic Oncology at the Catholic University of Leuven, European Union. 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